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95% CI: 0.321.00), though no significant effect was found on all-cause mortality (HR 0.81

The introduction of GLP-1s for weight loss has been a dysfunctional mess, thanks to pharmaceutical companies, insurance plans, pharmacy chains, and the federal government.

Through its unique mechanism of action as a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, as well as its impressive results in clinical trials, tirzepatide has the potential to completely transform the current approach to treating obesity

Investigators found GLP-1s are effective in helping kids and teens manage weight and diabetes, with no increase in serious mental health risks compared with placebo.

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