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Some people report: Appetite increase: Stronger hunger cues are the most common effect

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Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors a combination not seen in any currently licensed UK medicine

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Main similarities and differences in the effects of GLP-1 and GIP GIP and GLP-1 are incretin hormones with a common primary effect of stimulating insulin secretion in response to food intake, but with significant differences in additional physiological effects, particularly with regard to the regulation of glucagon secretion, effects on appetite and lipid metabolism, and bone metabolism

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A key part of their function is slowing down gastric emptying, which is the process of food moving from your stomach to your small intestine

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