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Finally, for diseases with conflicting data like AMD, a risk-benefit assessment framework is needed

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The study concluded that orlistat, combined with dietary intervention, is effective in achieving significant weight loss and reducing weight regain, along with improving obesity-related risk factors in obese patients [29]

however, our metaanalysis found that GLP1RA was not associated with reduced risk of the composite cardiovascular end point in a subgroup population with T2DM and CKD compared to placebo

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