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However, important limitations exist in the current evidence: Most studies have been relatively small with short follow-up periods Many participants had concurrent obesity, making it difficult to separate weight loss effects from direct effects on binge eating behaviour Long-term efficacy and safety data specifically for binge eating disorder are lacking The psychological and behavioural components of BED may require interventions beyond pharmacological appetite suppression There is no official link established by regulatory bodies between GLP-1 agonists and binge eating disorder treatment

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Liu D, Zhang Y, Liu Y, Hou L, Li S, Tian H, et al

Preliminary evidence suggests that a 12-Week treatment with tirzepatide plus low-energy ketogenic therapy is more effective than its combination with a low-calorie diet in preserving fat-free mass, muscle strength, and resting metabolic rate in patients with obesity

Hair loss can be caused by many factors and must be treated accordingly

As compared to mono or coagonists, the triagonist had enhanced effectiveness to decrease body weight and fat mass in rodents