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doi: 10.1007/s00125-005-1705-7

A centenary of gastrointestinal endocrinology
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Such dominance of a few large-scale trials may constrain the external validity of pooled estimates and obscure underlying heterogeneity across smaller studies

Weight loss typically occurs gradually and consistently over time, depending on dosage, adherence to the programme, and individual response
2018 Nov;74(11):1491

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