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This includes individuals with: Diagnosed MASLD or MASH, where GLP-1 therapy may offer therapeutic benefits but requires monitoring Chronic viral hepatitis (hepatitis B or C), particularly if transaminases are elevated Autoimmune hepatitis or other inflammatory liver conditions Cirrhosis or advanced fibrosis, where specialist consultation may be appropriate despite generally not requiring dose adjustment History of drug-induced liver injury from other agents For these patients, baseline comprehensive liver assessmentincluding liver enzymes, synthetic function tests (albumin, INR), and potentially imaging or non-invasive fibrosis markers (such as FIB-4 or ELF)helps establish a reference point for monitoring treatment effects

More serious but rare adverse effects can include pancreatitis and gallbladder disease

*Based on the 72-week ATTAIN-1 clinical trial with adults with overweight and obesity, taking orforglipron 17.2mg alongside a reduced-calorie diet and increased physical activity Who Is Orforglipron (Foundayo) GLP-1 Pill Suitable For

Start at 25% of the target dose and increase weekly

These medications include semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro, Zepbound), and liraglutide (Victoza, Saxenda)

Expected FDA decision Q3 2026