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41 The membrane depolarisation causes voltage-gated calcium channels in the cell membrane to open leading to calcium ion influx into the cell, which then results in the exocytosis of insulin vesicles stored in the cytoplasm

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Discussion According to this meta-analysis, AOMs resulted in significant weight loss while being used, followed by weight regain after treatment discontinuation

Slow injection techniquetaking 510 seconds to fully depress the plunger rather than 12 secondsallows tissue to accommodate the solution gradually and reduces pressure spikes that trigger pain

doi: 10.1038/sj.ijo.0803701

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