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27 These risks are not necessarily linear, 2 although some of the nonlinear effects that have been documented may reflect the fact that self-reported daily cigarette consumption is not a perfect marker for exposure, given that people may get more or less nicotine (and with it, harmful substances) out of each cigarette they smoke

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Smoking also contributes to a buildup of carbon monoxide in the blood, decreasing your oxygen levels and causing your leg muscles to tire more quickly