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Similar to the GO pathways, Hallmark pathway analysis revealed a decrease in genes associated with interferon-alpha responses
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Furthermore, the modified citrullinated proteins and PAD may create an altered molecule complex like the tissue transglutaminase and deaminated gluten in celiac disease, which may result in autoimmune reaction in genetically prone subjects

doi: 10.3390/app122010347 31 XiongH.GaoX.ZhangN.HeH.TangW.YangY.et al
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