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doi:10.1136/bmjopen-2015-007688

While they are generally considered safer than smoking, they are not without risks

Why is arsenic a problem

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Another issue with volado leaves is that they are prone to producing acrid off-flavors, either by organic design or from the impurities they pick up in the soil

Cholinergic receptors are located in several brain regions notably the midbrain tegmentum, the striatum, nucleus accumbens and the ventral tegmentum (VTA)
