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The only study currently available that collected questionnaire data on smoking and e-cigarettes in pregnant women 10 suggests that the use of e-cigarettes during pregnancy in 248 women causes fetal growth restriction, which in turn is a proposed risk factor for impaired lung function development and respiratory hyper-reactivity 11,12,13

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Following adjustments for the factors encompassed in model 1 and hypertension, diabetes, coronary heart disease, body mass index, physical activity, alcohol user, fish intake (model 2), consistency with model 1 was observed, with an OR of 1.36 (95% CI 1.131.63, p = 0.001)

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