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British journal of cancer, 2018

One study found that people who use both types of nicotine sources significantly raise their odds of cardiovascular disease

doi:10.1136/tc.2008.028241

Department of Health and Human Services, 2012

"Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene"

Marijuana Marijuana does carry its own mild risk for dependence and psychological addiction, and is now becoming legal for medicinal and recreational use throughout the U.S