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The fact that heavy smokers were 20 times more likely to die of lung cancer than non-smokers was dismissed as merely "a statistical association" that did not prove a cause and effect relationship

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Study suggests that estrogen may drive nicotine addiction in women A newly discovered feedback loop involving estrogen may explain why women might become dependent on nicotine more quickly and with less nicotine exposure than men

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Further, there are significant age differences in many of the acute neurobehavioural impacts of nicotine exposure 26

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