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The mechanisms of lung injury were considered further in the 1990, 2004, and 2006 reports (USDHHS 1990, 2004, 2006)

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Surgeon General's 1964 bombshell directly linking smoking to cancer and other diseases, were met with fierce denial and counter-messaging from a formidable tobacco industry

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Several unidentified compounds were identified in reference 36 that lacked chronic toxicity values precluding their risk estimation, adding to the overall uncertainty in the risk estimates (and likely bias towards underestimation)

This is in contrast to Altria, which generates the bulk of its revenue in the U.S., and Philip Morris International, which has been successful in the U.S