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Cyclosporine A-treated rats had attenuated lung edema, lung inflammation, upregulation of mitophagy related genes and improved oxygenation in comparison to untreated rats following mechanical ventilation-induced lung injury (Lin et al., 2018)

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In animal smoke exposure models, NLRP3 or GSDMD gene knockout mice exhibit reduced pulmonary inflammatory infiltration, decreased airway remodeling, and structural damage, further supporting the pathogenic role of pyroptosis in COPD progression at the in vivo level (96, 97)