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Nicotine increases with higher plant position

[18] [44] Inducing sex-reversal (causing the growth of opposite-sex flowers) of Cannabis is agriculturally useful because it allows hybridizing plants of the same genetic sex, producing seeds that are genetically single-sexed, which is in turn useful in the cannabinoid-focused sectors (medical and recreational cannabis) as they use female flowers as raw material

[22] At high doses it can cause nicotine poisoning and respiratory paralysis

130: S83-S89

Tolerance may also impact how a person performs everyday tasks, can cause interactions with other drugs or medications, and can increase the risk for alcoholism