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To study whether oxidative stress causes mtDNA damage, we assessed mtDNA damage by fragment PCR [31] and observed that hydrogen peroxide, gas phase cigarette smoke and CSE induced mtDNA damage in BEAS-2B cells [1, 26, 32, 33] (Online Additional file 1)

Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages

J Clin Periodontol 1997

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