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In a significant move, the FDA authorized the marketing of 20 Zyn products in early 2025, deeming them appropriate for the protection of public health based on lower toxicant levels compared to cigarettes and evidence supporting complete switching among some adult smokers, while imposing strict marketing restrictions to limit youth appeal (19)

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Furthermore, at therapeutic concentrations, varenicline is not an inhibitor of human renal transport proteins, as preclinical studies have shown