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The most important finding from our recent review update is that for the first time there is high certainty evidence that nicotine e-cigarettes are more effective than traditional nicotine-replacement therapies, such as patches, gum or lozenges, in helping people to quit smoking, said study co-author Ailsa Butler

Future investigations should integrate longitudinal human cohorts with mechanistic animal studies colonized by smoker-derived microbiota, which may provide causal insight into how specific taxa or metabolites mediate disease trajectories

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