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V., Gupta M

Host genetics and environment shape the composition of the gastrointestinal microbiome in nonhuman primates

But they would also have to (b) derive so little benefit from a low-risk substitute (either because they really dislike them or completely lost their taste for tobacco/nicotine) that it is not even worth its much lower cost. Moreover, the mere existence of lower-risk products alters the equation

No single measure is known that would have as great an impact on the number of deaths attributable to cancer as a reduction in the use of tobacco. An estimated 80% of tobacco users live in LMICs