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Even investigators who found that chronic cigarette smokers had significantly reduced plasma leptin levels propose that the low leptin levels reflect nicotine-induced enhancement of leptinreceptor binding or increased sensitivity of downstream transduction cascades (Hodge et al., 1997

doi: 10.1167/iovs.06-0644 157 LeitePELagrota-CandidoJMoraesLDEliaLPinheiroDFda SilvaRFet al
This effectively starves the skin of oxygen and nutrients, particularly vitamin A

Cigarettes hamper the blood supply that keeps skin tissue looking supple and healthy and breaks down collagen and elastin

In other words, your body doesnt grade on a curve just because the band is fancy

Ann Hematol 2009;88:68794 [DOI] [PubMed] [Google Scholar] 11.Kaufmann DA, Swenson EW
