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Like menthol, synthetic coolants are pharmacologically active at the cooling receptors lining the airways and oral cavity.7 20 35 36 Some evidence indicates that cooling agent WS-3 is more active at these receptors than menthol, generates stronger cooling sensations37 38 and may activate the sensory irritant receptor.3941 While menthol is perceived as minty, products with synthetic coolants could produce cooling sensations that mask nicotines harshness without providing a strong minty flavour.33 A clinical-laboratory human study found that administration of fruit, tobacco and mint flavoured e-cigarettes supplemented with WS-23 (vs no cooling agent) additive increased product appeal, smoothness and coolness and reduced bitterness and harshness.42 Additionally, e-cigarettes with cooling agent WS-23 were perceived as smoother, cooler and less harsh than those with menthol
Do people with mental illness and substance use disorders use tobacco more often

Deutsch-Wenzel, R., Brune, H

This is not the first time such evidence has come to light
