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The contraindications of Zepbound include: Having medullary thyroid cancer or MEN2 Doctors will likely not prescribe Zepbound for people with either: a personal or family history of medullary thyroid cancer, which is a rare type of thyroid cancer, or a personal history of MEN2, which is a rare genetic (inherited) condition For more details, see the Boxed warning section at the beginning of this article

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Nicotine and Stimulant Medications Amplified Effects with Stimulants Nicotine itself is a stimulant, and when combined with other stimulant medications like those used for ADHD (e.g., amphetamines or methylphenidate), it can increase heart rate and blood pressure more than either substance alone