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In the metabolic pathway of tryptophan metabolism, the genes related to indole-3-pyruvate monooxygenase and L-tryptophan--pyruvate aminotransferase ( LOC107816988 and LOC107791151 ) were up-regulated, which promoted the synthesis of auxin precursors to accelerate protein degradation (Liu et al., 2012)

Smokeless tobacco induced biophysical and biochemical alterations in the plasma, erythrocytes, and platelets of panmasala users: Subsequent biological effects Shaik Begum, Nagajothi G., Swarnalatha K., Vinod C., Narender K., Suresh C., Narendra Maddu Toxicology Reports 3

[DOI] [PubMed] [Google Scholar] Anthony JC, LeResche L, Niaz U, von Korff MR, Folstein MF

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Meanwhile, you may find that slowing down causes the pipe to go out