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The higher concentration of nicotine and other compounds in these products can lead to greater exposure and, potentially, more damage over time

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References 1.Jha P, Ramasundarahettige C, Landsman V, Rostron B, Thun M, Anderson RN, et al

Nicotine binds directly to nicotinic acetylcholine receptors in your prefrontal cortex, causing dopamine neurons in your ventral tegmental area to increase their firing rates