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96 In its final report released in July 2011, TPSAC concluded that "removal of menthol cigarettes from the marketplace would benefit public health in the United States." 97 In July 2013, FDA released an advance notice of public rulemaking (ANPRM) on a tobacco product standard for menthol in cigarettes, seeking comments, data, research, and any other relevant information

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The gut-associated lymphoid tissue (GALT), which constitutes the largest immune system tissue in the human body (over 70%), is a crucial reservoir of regulatory T cells (Tregs) and encompasses an extensive surface area of approximately 300 m2 (Vighi et al., 2008)