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Benzopyrene, a major polyaromatic hydrocarbon constituent of cigarette smoke, has been recently shown to regulate Langerhans cell migration and Th2- and Th17-profile cytokine production during epicutaneous sensitization response [62]

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Elevated myosin heavy chain and decreased Sarco/endoplasmic reticulum calcium-ATPase (SERCA2a) suggest aberrant calcium cycling at the molecular level (183)