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1558 First attempt at tobacco cultivation in Europe fail

Manufactured with attention to quality and consistency, making it suitable for export markets

Sponsor for the purpose of the secondary listing Merrill Lynch South Africa (Pty) Ltd t/a BofA Securities Representative office in South Africa Waterway House South No 3 Dock Road, V&A Waterfront, Cape Town 8000, South Africa PO Box 631, Cape Town 8000, South Africa tel: +27 21 003 6500 Manage your shareholding Ordinary shareholder enquiries United Kingdom Registrar Computershare Investor Services PLC (Computershare) The Pavilions, Bridgwater Road, Bristol BS99 6ZZ tel: 0800 408 0094 (UK only) or +44 370 889 3159 (Overseas) online: www.investorcentre.co.uk/contactus South African Registrar Computershare Investor Services Proprietary Limited Private Bag X9000, Saxonwold, 2132, South Africa tel: 0861 100 634

The sampling scheme used to constitute the subsample sought to obtain a diverse mix of tobacco product use patterns by sampling from mutually exclusive user groups including exclusive current cigarette users, current users of other tobacco products, experimental-only users of any tobacco product, former users of tobacco products and never users

Occasionally colonists paid Native Americans for land in order to reduce the risk of being attacked but private land sales by Native Americans to individual colonists were discouraged

Combined pharmacologic and behavioural approaches were also effective (52 RCTs, n = 19 488