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Call your doctor right away or seek immediate medical care if you have: Bleeding Breathing problems, such as shortness of breath, difficulty breathing, labored breathing, or wheezing Change in alertness, such as passing out, unresponsiveness, or confusion Chest pain, chest tightness, chest pressure, or palpitations Fever

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Nicotine reaches the brain within seconds after inhaling it, according to the American Cancer Society (ACS)

Gruber 2001)

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Many people who use cocaine may use multiple methods of ingestion, and they may also have polysubstance dependence