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Differentially abundant metabolites between TSP and T were primarily enriched in carbohydrate metabolic pathways, such as nucleotide sugar biosynthesis, fructose, and mannose metabolism

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To estimate the impact of implementing plain tobacco packaging, advertising bans or smoke-free air, the smoking prevalence post-intervention was calculated as follows: Prevalence post =Prevalance pre [(E m E c )/(1 E c )I p Prevalence pre ] where Prevalence pre is prevalence of people who smoke before the intervention, I p is variation proportion in consumption affecting this prevalence, E m is the expected effectiveness of fully implementing the intervention, and E c is the effectiveness being achieved (if any) with current measures (expressed as relative reduction in tobacco consumption)

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