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Yet, important knowledge gaps remain on dPOD e-cigarettes, including studies on the most popular brands on the market, an understanding of where metals and metalloids in the aerosols may originate, mechanisms of metal and metalloid release over the device life cycle, and the oxidation state (and thus toxicological risk) of Cr and Sb

However, under specific conditions, this "gate" can malfunction, leading to the reflux of stomach acid and partially digested food into the esophagus, throat, mouth, or even the respiratory tract, causing discomfort

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