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"Treatment" of sad emotional states with nicotine over time may also impair innate restorative responses, just as treatment of chronic pain with opioids results in many patients experiencing hyperalgesia, a pathologically heightened response to painful stimuli

Smoking and tobacco control monograph, 7, 5975

Results revealed that treatment with the miR-34a-5p mimic at a dose of 1 nmol led to an approximately 4-fold increase in hepatic miR-34a-5p expression (Supplementary Figure S2A)

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Feder-Mengus C, Ghosh S, Weber WP, Wyler S, Zajac P, Terracciano L, et al

NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis