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The insertion/deletion polymorphism 1G-1607/2G in the promoter region of MMP1 , which increases transcription due to the introduction of a new binding site for the ETS-1 transcription factor 118 , has been evaluated in relation to lung function decline, with controversial results 119 , 120

Due to the high number of smokers in Indonesia, Gudang Garam as well as other companies in Indonesias cigarette industry is a major source of revenue for the Indonesian government in terms of excise duties and corporate income tax

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However, Murphys death scene in the film is emotionally raw and powerful, reflecting her range as a trained actor