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doi: 10.1111/j.1528-1167.2009.02268.x [DOI] [PMC free article] [PubMed] [Google Scholar] 14.Becchetti A, Grandi LC, Cerina M, Amadeo A

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The relationship of a smoker's melanosis (dark-brown foci) and inflammatory changes that result from heat, smoke, and inhalation with the absorption of exogenous pigments has not been determined

Tolerance takes time to build, and it varies from person to person and strain to strain