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Darkis explained in this letter that L&M filters used a "highly purified alpha cellulose" that was "entirely harmless" and "effectively filtered the smoke"

Later work demonstrated that the combined absence of the p53 target genes encoding the pro-apoptotic BH3-only proteins PUMA and NOXA (and to a lesser extent loss of PUMA alone) rendered lymphoid cells as resistant to DNA damage-inducing agents as loss of p53 itself [8, 9, 22]

miR-34c works downstream of p53 leading to dairy goat male germline stem-cell (mGSCs) apoptosis

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Wolff S, Erster S, Palacios G, Moll UM