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2-Hydroxylation of nicotine was shown to produce 4-(methylamino)-1-(3-pyridyl)-1-butanone with 2-hydroxynicotine as an intermediate

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Tran CT, Bosilkovska M, de La Bourdonnaye G, Blanc N, Haziza C (2020) Reduced levels of biomarkers of exposure in smokers switching to the carbon-heated tobacco product 1.0: a controlled, randomized, open-label 5-day exposure trial

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