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High blood levels of the compound prevent a sufficient amount of oxygen from reaching the heart and brain which can cause choking, capillary bleeding, permanent damage to nerve tissue and brain cells, and in severe cases, death

Aripiprazoles mechanism is distinct: it is a dopamine D2 partial agonist and serotonin 5HT1A partial agonist/5HT2A antagonist

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Hence, we cannot understate the significance of generational shifts in smoking behavior due to the social norms at a given point in time that signaled acceptability or disapproval of cigarette use, independent of, and beyond, the addictive properties of tobacco