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The mechanism is not one pathway but four separate biological insults working together

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The modern form emerged with the 2003 patent by Hon Lik for a nicotine delivery system that vaporized liquid to deliver nicotine to the user in an aerosol, leading to sales of the first e-cigarette in 2004 in China [46]

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J Neurosci 23:1122411228 Shin AH, Kim HJ, Thayer SA (2012) Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat