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[14] Winston overtook Pall Mall cigarettes as the #1 cigarette in the United States in 1966, while the advertising campaign continued to make an impression on the mass media

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Similarly, smokeless tobacco consumption altered the oral microbiome, increasing inflammation-associated species and resembling the microbiome of OSCC patients

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As the disease progresses, patients may develop worsening dyspnea, recurrent exacerbations, and complications such as pulmonary hypertension and right-sided heart failure