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Ethics declarations Ethics approval and consent to participate This simulation model-based research was approved by the Mass General Brigham Human Research Committee (Protocol #2019P001772)

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[ IV ] Kadimpati S, Hoelzer BC, Hooten WM, Warner DO

This study shows that a median dose above 500Gy is well tolerated for small HCCs, which increases our confidence in treating aggressively when appropriate. Before FDA approval, resin microspheres were used off label for HCC at Villalobos institution, however, insights gained from DOORwaY 90 have acted as a long-awaited confirmation of the efficacy of resin microspheres