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Other reported enzymes involved in starch degradation are glucan water dikinase and -amylase, but they are more important during growing, and less during leaf processing

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In 2022, a systematic review by the University of Bath's Tobacco Control Research Group which receives funding from Bloomberg Philanthropies and are part of STOP, a global tobacco industry watchdog concluded that PMI's clinical trials of its heated tobacco products were of poor quality and at high risk of bias

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