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This approach was considered the most relevant exposure framework for a cross-sectional analysis of prevalent hypertension, as current behaviour is more directly related to present-day cardiovascular risk than past experimentation with e-cigarettes

The first temporal derivative of this time-series was also included in the model

Vapes that can be refilled with new cartridges or tanks will still be available

The present study showed that such an effect cannot be solely attributed to tobacco and its components, as tobacco-free cigarette smoke promoted inflammatory cellular inflow in the bronchoalveolar lavage, suggesting the presence of a local inflammatory process

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