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The authors have no commercial conflicts of interest to disclose

Carefully and manually selected tobacco leaves , of different varieties Virginia, Burley grown in different countries are used to produce Cigaretto

Dr Fagerstrom opened his first smokers' clinic in 1975, and recognised similar traits in smokers as drug addicts

**Based on the totality of evidence available for IQOS in comparison with continuing to smoke

If concerned that elevated caffeine levels are causing added anxiety, applying the 1997 study's finding of a doubling suggests that, at least temporarily, a caffeine reduction of roughly half may be of benefit

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