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During the past decade and a half, a number of medical people have produced an increasing weight of evidence showing that an association exists between peoples smoking habits and the incidence of various diseases, including coronary heart disease, chronic bronchitis, emphysema, and lung cancer

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For example, AHRR , a tumor suppressor gene on chromosome 5p15.33, encodes a class E basic helixloophelix protein that dampens the translocation of AHRligand complex to the nucleus

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