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Cigarette smoke constituents cause endothelial nitric oxide synthase dysfunction and uncoupling due to depletion of tetrahydrobiopterin with degradation of GTP cyclohydrolase

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These are the things that Don Draper's Madison Avenue advertising agency would have been selling to the American people during those colourful, optimistic postwar boom years of the Fifties and Sixties, and they feature heavily in this vast, two-volume collection of digitally restored real print ads from the period

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And nicotine dependency is every bit as real and permanent as alcoholism