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Apart from the recognised factors that affect substance use disorders in general, examination of the particular association between smoking and schizophrenia raises three main possible hypotheses: first, patients smoke at an increased frequency because smoking ameliorates some of the symptoms of schizophrenia and side-effects of medication second, smoking causes an increased predisposition to develop psychosis third, common genetic risk factors make some individuals more vulnerable to developing schizophrenia and nicotine dependence

At the same time, a growing proportion of total smokers use fewer than 10 cigarettes a day, said Neal Freedman, another NCI researcher involved in the study

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