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Asthma and tobacco smoke

Estrogen deficiency due to menopause results in accumulation of the transcription factor hypoxia inducible factor 1 alpha (HIF1) in osteoclasts, in turn promoting osteoclast activation and bone loss 5

This is because the body hasnt yet become accustomed to nicotines effects

Smoking can cause blockages and narrowing in your arteries, which means less blood and oxygen flow to your heart

[DOI] [PubMed] [Google Scholar] 3.Barreto SG