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Section 301(b)(4) of the Public Health Service Act, as amended by Section 262, Pub

This urine content of smoke particulates is why smoke can cause bladder and urinary tract cancers and can also allow for the measuring of how much a person or animal has been exposed to smoke

in addition to being a component of cell membranes, it is a precursor for the synthesis of bile acids, vitamin D, and various steroid hormones, making it an essential component of animal tissues and cells

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