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Acetylcholine is the natural agonist for the same receptors that bind nicotine, which are particularly concentrated in the central nervous system (brain and spinal cord)
[DOI] [PMC free article] [PubMed] [Google Scholar] 27.World Health Organization

However, Bic alone has sold more than 30 billion
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Produced by Philip Morris USA (a subsidiary of Altria), Marlboro is the best-selling cigarette brand in the United States and one of the most recognized tobacco brands in the world