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Smoking is a leading cause of preventable diseases, including lung cancer, heart disease, stroke, and respiratory disorders

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A priori power analyses were conducted using G*Power v3.1.9.2, determining that a sample size of 40 would adequately detect a significant small-to-medium effect ( p 2 = .05, = 0.05, within-subject correlation = 0.5) of the 2 2 between-within subject interaction on a continuous outcome with 80% power

We identified three outcomes with a 4-star association with smoking: COPD (72% increase in risk based on the BPRF, 0.54 ROS), lower respiratory tract infection (54%, 0.43) and pancreatic cancer (52%, 0.42)

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